1
عمومی::
فاکتور انعقادی
Because the cirrhotic liver already has significantly reduced numbers of hepatocytes, the ischemic injury to the remaining hepatocytes is manifested in decreased synthetic function with insufficient generation of criti- cal proteins such as clotting factors and albumin.
Hypothermia, the scourge of trauma care, can magnify coagulopathy through its negative effects on clotting factors.
Circulating clotting factors undergo a cascading activation that eventually leads to the activation of thrombin that converts fibrinogen to fibrin.
Cross linking of fibrin monomers forms a strengthening lattice, reinforcing the platelet plug. ftrombin is one of the most important proteins in the coagulation cascade because it activates numerous other clotting factors; increases platelet activation and aggregation; and activates protein C, which is a modulating inhibitor of the cascade. ftere are two coagula- tion pathways, intrinsic and extrinsic, that coalesce into a common pathway where factor X is activated and converts prothrombin to thrombin and ultimately to deposition of fibrin. fte effectiveness of the intrinsic pathway is typically measured by the partial
As previously stated, activation of clotting factors is coupled to the simultaneous activation of clotting inhibitors so that clotting is carefully coun- tered by fibrinolysis.
واژگان شبکه مترجمین ایران